Systems genetics links Bicc1 to bone development
نویسندگان
چکیده
منابع مشابه
Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.
Genetic defects in autosomal-dominant polycystic kidney disease (ADPKD) promote cystic growth of renal tubules, at least in part by stimulating the accumulation of cAMP. How renal cAMP levels are regulated is incompletely understood. We show that cAMP and the expression of its synthetic enzyme adenylate cyclase-6 (AC6) are up-regulated in cystic kidneys of Bicc1(-)(/-) knockout mice. Bicc1, a p...
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Bicc1 is a mouse homologue of Drosophila Bicaudal-C (dBic-C), which encodes an RNA-binding protein. Orthologs of dBic-C have been identified in many species, from C. elegans to humans. Bicc1-mutant mice exhibit a cystic phenotype in the kidney that is very similar to human polycystic kidney disease. Even though many studies have explored the gene characteristics and its functions in multiple sp...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2014
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2014.77